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Literature summary extracted from

  • Xu, H.; Han, Y.; Liu, B.; Li, R.
    Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-alpha-acetyltransferase 10 (Naa10) (2016), Sci. Rep., 6, 38508 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.255 gene NAA10, real-time reverse transcription-PCR enzyme expression analysis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.255 additional information construction of Naa10 stably knocked down H1299 cell line H1299-shNaa10, cDNA microarray analysis Homo sapiens
2.3.1.255 additional information silencing of mouse immortalized embryonic endothelial cells Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.255 Homo sapiens P41227
-
-
2.3.1.255 Mus musculus Q9QY36
-
-
2.3.1.255 Mus musculus C57 Q9QY36
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.255 embryo caudal half region, immortalized embryonic endothelial cells Mus musculus
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2.3.1.255 endothelial cell immortalized embryonic endothelial cells Mus musculus
-
2.3.1.255 NCI-H1299 cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.3.1.255 N-alpha-acetyltransferase 10
-
 Homo sapiens
2.3.1.255 N-alpha-acetyltransferase 10
-
 Mus musculus
2.3.1.255 NAA10
-
 Homo sapiens
2.3.1.255 NAA10
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.255 acetyl-CoA
-
 Homo sapiens
2.3.1.255 acetyl-CoA
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.1.255 malfunction measuring the different time points of gene expression upon Naa10 siRNA treatment, NTN1 and its receptor UNC5B are found to be the most dramatically overexpressed among the genes involved in morphogenesis Mus musculus
2.3.1.255 malfunction measuring the different time points of gene expression upon Naa10 siRNA treatment, NTN1 and its receptor UNC5B are found to be the most dramatically overexpressed among the genes involved in morphogenesis. Analysis of upregulated genes in Naa10 stably knocked down H1299 cell line, overview Homo sapiens
2.3.1.255 physiological function N-alpha-acetyltransferase 10 (Naa10) is the catalytic subunit of N-acetyltransferase A (NatA), it catalyzes N-alpha-acetylation, epsilon-acetylation, as well as autoacetylation. The alpha (N-terminal) acetyltransferase functions as a major modulator of cell growth and differentiation. Potential function of Naa10 in cell morphogenesis. Negative regulation of Naa10 towards NTN1 and its receptor UNC5B are detected upon treatment of all-trans retinoid acid, used to induce morphological differentiation. UNC-5 Homolog B (UNC5b), a dependence receptor of netrin-1, plays an essential role in mediating the repulsive effect of axonal migration and blood vessel formation through association with its ligand netrin-1 (NTN1). In addition, UNC5B has also been indicated as a putative tumor suppressor gene in numerous cancers Homo sapiens
2.3.1.255 physiological function N-alpha-acetyltransferase 10 (Naa10) is the catalytic subunit of N-acetyltransferase A (NatA), it catalyzes N-alpha-acetylation, epsilon-acetylation, as well as autoacetylation. The alpha (N-terminal) acetyltransferase functions as a major modulator of cell growth and differentiation. Potential function of Naa10 in cell morphogenesis. Negative regulation of Naa10 towards NTN1 and its receptor UNC5B are detected upon treatment of all-trans retinoid acid, usedto induce morphological differentiation. UNC-5 Homolog B (UNC5b), a dependence receptor of netrin-1, plays an essential role in mediating the repulsive effect of axonal migration and blood vessel formation through association with its ligand netrin-1 (NTN1). In addition, UNC5B has also been indicated as a putative tumor suppressor gene in numerous cancers Mus musculus